ABD 3e Chapter 1
Understand the major goal of statistics
Distinguish between a sample and a population
Distinguish between an estimate and a parameter
Identify why estimates from samples may deviate from parameters of populations
Identify the properties of a good sample
Goal: We want to learn about the world.
Challenge: We can’t look at the whole world.
Solution: Take a sample and generalize outward.
New Challenge: Samples deviate from the populations by Bad luck (sampling error) or Unrepresentative sampling (sampling bias)
Question:
How do we make inferences about the WORLD from our finite observations?
Answer:
Make models to account for the process of sampling and the associated hazards
Volunteers for a study are likely to be different, on average, from the population.
Examples:
Volunteers for sex surveys are more likely to be open about sex.
Volunteers for medical studies may be sicker than the general population.
Animals that are caught may be slower or more docile than those that are not.
Taking random samples is hard and requires effort
When units are chosen at random from a population, it is called a random sample
Random sampling minimizes bias and allows for estimation of sampling error
Rules:
Each unit should have an equal chance of being included in a sample
Selection of units must be independent
All statistics we do assumes a random sample
Carefully characterize a population and use computer code (e.g. the sample() function in R) to select participants randomly.
Sampling Error:
Even if you sample perfectly, by the book, your estimates will differ from the true parameter by chance.
Because an estimate is a random variable, the value of an estimate is influenced by chance

BIOL 275 Biostatistics | Spring 2026